Ontology highlight
ABSTRACT:
SUBMITTER: Wu H
PROVIDER: S-EPMC5400568 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Wu Hao H Wu Runliu R Chen Miao M Li Daojiang D Dai Jing J Zhang Yi Y Gao Kai K Yu Jun J Hu Gui G Guo Yihang Y Lin Changwei C Li Xiaorong X
Oncotarget 20170301 13
<h4>Background</h4>Growing evidence suggests that long non-coding RNAs (lncRNAs) play a key role in tumorigenesis. However, the mechanism remains largely unknown.<h4>Results</h4>Thousands of significantly dysregulated lncRNAs and mRNAs were identified by microarray. Furthermore, a miR-133b-meditated lncRNA-mRNA ceRNA network was revealed, a subset of which was validated in 14 paired CRC patient tumor/non-tumor samples. Gene set enrichment analysis (GSEA) results demonstrated that lncRNAs ENST000 ...[more]