Ontology highlight
ABSTRACT:
SUBMITTER: Yuan X
PROVIDER: S-EPMC5400611 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Yuan Xun X Kho Dhonghyo D Xu Jing J Gajan Ambikai A Wu Kongming K Wu Gen Sheng GS
Oncotarget 20170301 13
ONC201 was previously identified as a first-in-class antitumor agent and small-molecule inducer of the TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) gene that induces apoptosis in cancer cells. ONC201 has a safety profile and is currently in phase II clinical trials for the treatment of various malignancies. In the current study, we examine the effect of ONC201 on triple-negative breast cancer cells (TNBC), a subtype of breast cancer that is sensitive to TRAIL. We find that ONC ...[more]