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Impact of ethnicity on the outcome of men with metastatic, hormone-sensitive prostate cancer.


ABSTRACT: BACKGROUND:Prostate cancer (PCa) outcomes are impacted by socioeconomic and biologic factors. Ethnicity plays a role in the former, but little is known about the responsiveness of metastatic PCa to androgen-deprivation therapy (ADT) among races. METHODS:The Surveillance, Epidemiology, and End Results (SEER) registry was used to identify men who were diagnosed with distant, de novo, metastatic PCa from 2004 to 2012. Patterns of presentation, overall survival (OS), and PCa-specific mortality (PCSM) were determined for each race. E3805 clinical trial data also were retrospectively reviewed to assess outcomes of ADT and ADT plus docetaxel by race. RESULTS:Of all PCa diagnoses in SEER, distant, de novo, metastatic disease was diagnosed in 4.2% of non-Hispanic whites, 5.8% of Hispanic whites, 5.7% of blacks, 5.5% of Asians/Pacific Islanders, and 8.8% of American Indians/Alaska Natives (P?

SUBMITTER: Bernard B 

PROVIDER: S-EPMC5400707 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Impact of ethnicity on the outcome of men with metastatic, hormone-sensitive prostate cancer.

Bernard Brandon B   Muralidhar Vinayak V   Chen Yu-Hui YH   Sridhar Srikala S SS   Mitchell Edith P EP   Pettaway Curtis A CA   Carducci Michael A MA   Nguyen Paul L PL   Sweeney Christopher J CJ  

Cancer 20170105 9


<h4>Background</h4>Prostate cancer (PCa) outcomes are impacted by socioeconomic and biologic factors. Ethnicity plays a role in the former, but little is known about the responsiveness of metastatic PCa to androgen-deprivation therapy (ADT) among races.<h4>Methods</h4>The Surveillance, Epidemiology, and End Results (SEER) registry was used to identify men who were diagnosed with distant, de novo, metastatic PCa from 2004 to 2012. Patterns of presentation, overall survival (OS), and PCa-specific  ...[more]

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