Spectrally selective three-dimensional dynamic balanced steady-state free precession for hyperpolarized C-13 metabolic imaging with spectrally selective radiofrequency pulses.

ABSTRACT:

Purpose

Balanced steady-state free precession (bSSFP) sequences can provide superior signal-to-noise ratio efficiency for hyperpolarized (HP) carbon-13 (¹³ C) magnetic resonance imaging by efficiently utilizing the nonrecoverable magnetization, but managing their spectral response is challenging in the context of metabolic imaging. A new spectrally selective bSSFP sequence was developed for fast imaging of multiple HP ¹³ C metabolites with high spatiotemporal resolution.

Theory and methods

This novel approach for bSSFP spectral selectivity incorporates optimized short-duration spectrally selective radiofrequency pulses within a bSSFP pulse train and a carefully chosen repetition time to avoid banding artifacts.

Results

The sequence enabled subsec

SUBMITTER: Shang H 

PROVIDER: S-EPMC5400740 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature