Dataset Information

Associations between matrix metalloproteinase gene polymorphisms and glaucoma susceptibility: a meta-analysis.

ABSTRACT: Matrix metalloproteinases (MMPs) polymorphisms have been implicated in the pathogenesis of glaucoma risk. However, the results were controversial. We performed a meta-analysis to evaluate the precise associations between MMPs polymorphisms and glaucoma risk.Related studies were reviewed by searching electronic databases within four databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the association between the most common polymorphisms of MMPs and glaucoma risk. Heterogeneity, publication bias and sensitivity analysis were conducted to guarantee the statistical power.Overall, 11 selected articles involving 2,388 cases and 2,319 controls were included in this meta-analysis. Significant associations were only found between MMP-9 rs17576 G?>?A polymorphism (GA vs. GG: OR?=?0.80, 95%CI?=?0.67-0.97, P?=?0.02, I2?=?0%), MMP-9 rs3918249 C?>?T polymorphism (TT vs. CC?+?CT: OR?=?0.71, 95%CI?=?0.51-0.98, P?=?0.04, I2?=?0%) and glaucoma risk in the general population. Subgroup analysis also suggested that MMP-9 rs17576 G?>?A was related to glaucoma in the Caucasian population (GA vs. GG: OR?=?0.67, 95%CI?=?0.45-1.00, P?=?0.05; GA?+?AA vs. GG: OR?=?0.66, 95%CI?=?0.45-0.97, P?=?0.03, I2?=?0%).Our meta-analysis demonstrates that MMP-9 rs17576 G?>?A polymorphism might be a protective factor against the development of glaucoma in Caucasian population.

SUBMITTER: Wu MY

PROVIDER: S-EPMC5401566 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Associations between matrix metalloproteinase gene polymorphisms and glaucoma susceptibility: a meta-analysis.

Wu Ming-Yue MY Wu Yang Y Zhang Yong Y Liu Cai-Yun CY Deng Chun-Yan CY Peng Le L Zhou Lan L

BMC ophthalmology 20170421 1

<h4>Background</h4>Matrix metalloproteinases (MMPs) polymorphisms have been implicated in the pathogenesis of glaucoma risk. However, the results were controversial. We performed a meta-analysis to evaluate the precise associations between MMPs polymorphisms and glaucoma risk.<h4>Methods</h4>Related studies were reviewed by searching electronic databases within four databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the association between the most common ...[more]

PMID: 28431514

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Project description:BackgroundTendon-ligament injuries (TLIs), including Achilles tendinopathy, cruciate ligament injury, tennis elbow, rotator cuff injury, patellar tendinopathy, and tibial tendinopathy, are common musculoskeletal soft injuries during physical activity. Matrix metalloproteinase-3 (MMP-3) gene polymorphisms have been implicated in the etiology of TLIs in several genetic association studies with inconsistent results. The purpose of this study was to collect and synthesize the current evidences on the association of MMP-3 polymorphisms and TLIs.MethodsThe search was conducted using PubMed, Web of Science, EMBASE, Cochrane Library, CNKI and Wanfang databases, prior to July, 2021. Newcastle Ottawa Scale was used to appraise the study quality. Strengths of association were represented by odds ratios (ORs) and 95% confidence intervals (95% CIs).ResultsThirteen studies with 2871 cases and 4497 controls met the eligibility criteria, and each study was in high quality. The overall analyzes suggested rs3025058 was associated with an increased TLIs risk (5A vs. 6A, OR = 1.20, 95% CI 1.03-1.40, P = 0.020). However, the association was not found for rs679620, rs591058, and rs650108 polymorphisms. Subgroup analysis by injury type suggested that rs679620 polymorphism was associated with a reduced risk to Achilles tendon rupture (AA + AG vs. GG, OR = 0.46, 95% CI 0.25-0.87, P = 0.020), and rs3025058 was associated with an elevated risk to anterior cruciate ligament injury (5A5A + 5A6A vs. 6A6A, OR = 1.46, 95% CI 1.03-2.06, P = 0.030). When stratified by ethnicity, the findings indicated that rs3025058 polymorphism was associated with an increased TLIs risk among Caucasians (5A6A vs. 6A6A, OR = 1.55, 95% CI 1.09-2.42, P = 0.020) and Brazilians (5A5A vs. 5A6A + 6A6A, OR = 2.80, 95% CI 1.44-5.45, P = 0.002).ConclusionFindings of this study suggest that rs679620 polymorphism is associated with a reduced Achilles tendon rupture risk, and rs3025058 polymorphism contributes to an increased TLIs risk in Caucasians and Brazilians. However, rs591058 and rs650108 polymorphisms do not show any association with TLIs.

Dataset Information

Associations between matrix metalloproteinase gene polymorphisms and glaucoma susceptibility: a meta-analysis.

Publications

Associations between matrix metalloproteinase gene polymorphisms and glaucoma susceptibility: a meta-analysis.

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