Ontology highlight
ABSTRACT:
SUBMITTER: Haberman RP
PROVIDER: S-EPMC5401793 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Haberman Rebecca P RP Koh Ming Teng MT Gallagher Michela M
Neurobiology of aging 20170103
Elevated excitability in the hippocampus has emerged as a key contributor to reduced memory function in aging and in cognitive impairment prodromal to Alzheimer's disease. Here, we investigated the relationship between neural activity and memory in the hippocampus and a connectional cortical network using an aged rat model of individual differences for memory impairment. The expression of cFos was used as a measure of pharmacologically induced neural activity. Aged memory-impaired rats exhibited ...[more]