Ontology highlight
ABSTRACT:
SUBMITTER: Khodanovich MY
PROVIDER: S-EPMC5402392 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Khodanovich Marina Yu MY Sorokina Irina V IV Glazacheva Valentina Yu VY Akulov Andrey E AE Nemirovich-Danchenko Nikolay M NM Romashchenko Alexander V AV Tolstikova Tatyana G TG Mustafina Lilia R LR Yarnykh Vasily L VL
Scientific reports 20170424
Cuprizone-induced demyelination in mice is a frequently used model in preclinical multiple sclerosis research. A recent quantitative clinically-targeted MRI method, fast macromolecular proton fraction (MPF) mapping demonstrated a promise as a myelin biomarker in human and animal studies with a particular advantage of sensitivity to both white matter (WM) and gray matter (GM) demyelination. This study aimed to histologically validate the capability of MPF mapping to quantify myelin loss in brain ...[more]