Cellular immune profiling after sequential clofarabine and lenalidomide for high risk myelodysplastic syndromes and acute myeloid leukemia.
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ABSTRACT:
SUBMITTER: Jain P
PROVIDER: S-EPMC5402630 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Cellular immune profiling after sequential clofarabine and lenalidomide for high risk myelodysplastic syndromes and acute myeloid leukemia.
Jain Prachi P Klotz Jeffrey J Dunavin Neil N Lu Kit K Koklanaris Eleftheria E Draper Debbie D Superata Jeanine J Chinian Fariba F Yu Quan Q Keyvanfar Keyvan K Wong Susan S Muranski Pawel P Barrett A John AJ Ito Sawa S Battiwalla Minoo M
Leukemia research reports 20170413
Patients with high risk myelodysplastic syndromes (MDS) and acute myelogenous leukemia (AML) are commonly older with multiple co-morbidities, rendering them unsuitable for intensive induction chemotherapy or transplantation. We report preliminary cellular immune profiling of four cases receiving sequential clofarabine and lenalidomide for high risk MDS and AML in a phase I study. Our results highlight the potential of immune profiling for monitoring immune-modifying agents in high risk MDS and A ...[more]
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