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Islet cell transplant: Update on current clinical trials.


ABSTRACT: In the last 15 years clinical islet transplantation has made the leap from experimental procedure to standard of care for a highly selective group of patients. Due to a risk-benefit calculation involving the required systemic immunosuppression the procedure is only considered in patients with type 1 diabetes, complicated by severe hypoglycemia or end stage renal disease. In this review we summarize current outcomes of the procedure and take a look at ongoing and future improvements and refinements of beta cell therapy.

SUBMITTER: Schuetz C 

PROVIDER: S-EPMC5403130 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Islet cell transplant: Update on current clinical trials.

Schuetz Christian C   Markmann James F JF  

Current transplantation reports 20160517 3


In the last 15 years clinical islet transplantation has made the leap from experimental procedure to standard of care for a highly selective group of patients. Due to a risk-benefit calculation involving the required systemic immunosuppression the procedure is only considered in patients with type 1 diabetes, complicated by severe hypoglycemia or end stage renal disease. In this review we summarize current outcomes of the procedure and take a look at ongoing and future improvements and refinemen  ...[more]

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