Ontology highlight
ABSTRACT:
SUBMITTER: Rocca A
PROVIDER: S-EPMC5403877 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Rocca Andrea A Cecconetto Lorenzo L Passardi Alessandro A Melegari Elisabetta E Andreis Daniele D Monti Manuela M Maltoni Roberta R Sarti Samanta S Pietri Elisabetta E Schirone Alessio A Fabbri Francesco F Donati Caterina C Nanni Oriana O Fedeli Anna A Faedi Marina M Amadori Dino D
Cancer chemotherapy and pharmacology 20170324 5
<h4>Purpose</h4>Combination of anthracyclines with trastuzumab is hampered by cardiotoxicity. Pegylated liposomal doxorubicin and lapatinib could represent a safer alternative to combination therapy.<h4>Methods</h4>In this phase Ib study with 3 + 3 dose escalation design, patients with HER2-positive advanced breast cancer received pegylated liposomal doxorubicin 30 mg/m<sup>2</sup> intravenously on day 1 plus lapatinib 1250 (level 1) or 1500 (level 2) mg/day orally on days 1-21 of each 21-day cy ...[more]