Nitrotriazole-Based Compounds as Antichagasic Agents in a Long-Treatment In Vivo Assay.

ABSTRACT: 3-Nitrotriazole-based compounds belonging to various chemical subclasses were found to be very effective against Chagas disease both in vitro and in vivo after a short administration schedule. In this study, five compounds with specific characteristics were selected to be administered for longer periods of time to mice infected with the virulent Trypanosoma cruzi Y strain to further evaluate their effectiveness as antichagasic agents and whether or not potential adverse effects occur. Benznidazole was included for comparison purposes. Complete parasitemia depletion, weight gain, 100% survival, and a lack of myocardial inflammation were observed with four of the compounds and benznidazole administered intraperitoneally at 15 or 20 mg/kg of body weight/day for 40 days. There was a significan

SUBMITTER: Papadopoulou MV 

PROVIDER: S-EPMC5404586 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature