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RGMs: Structural Insights, Molecular Regulation, and Downstream Signaling.

ABSTRACT: Although originally discovered as neuronal growth cone-collapsing factors, repulsive guidance molecules (RGMs) are now known as key players in many fundamental processes, such as cell migration, differentiation, iron homeostasis, and apoptosis, during the development and homeostasis of many tissues and organs, including the nervous, skeletal, and immune systems. Furthermore, three RGMs (RGMa, RGMb/DRAGON, and RGMc/hemojuvelin) have been linked to the pathogenesis of various disorders ranging from multiple sclerosis (MS) to cancer and juvenile hemochromatosis (JHH). While the molecular details of these (patho)biological effects and signaling modes have long remained unknown, recent studies unveil several exciting and novel aspects of RGM processing, ligand-receptor interactions, and downstream signaling. In this review, we highlight recent advances in the mechanisms-of-action and function of RGM proteins.

SUBMITTER: Siebold C

PROVIDER: S-EPMC5404723 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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RGMs: Structural Insights, Molecular Regulation, and Downstream Signaling.

Siebold Christian C Yamashita Toshihide T Monnier Philippe P PP Mueller Bernhard K BK Pasterkamp R Jeroen RJ

Trends in cell biology 20161219 5

Although originally discovered as neuronal growth cone-collapsing factors, repulsive guidance molecules (RGMs) are now known as key players in many fundamental processes, such as cell migration, differentiation, iron homeostasis, and apoptosis, during the development and homeostasis of many tissues and organs, including the nervous, skeletal, and immune systems. Furthermore, three RGMs (RGMa, RGMb/DRAGON, and RGMc/hemojuvelin) have been linked to the pathogenesis of various disorders ranging fro ...[more]

PMID: 28007423

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