Ontology highlight
ABSTRACT:
SUBMITTER: Larhammar M
PROVIDER: S-EPMC5404924 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
eLife 20170425
The PKR-like endoplasmic reticulum kinase (PERK) arm of the Integrated Stress Response (ISR) is implicated in neurodegenerative disease, although the regulators and consequences of PERK activation following neuronal injury are poorly understood. Here we show that PERK signaling is a component of the mouse MAP kinase neuronal stress response controlled by the Dual Leucine Zipper Kinase (DLK) and contributes to DLK-mediated neurodegeneration. We find that DLK-activating insults ranging from nerve ...[more]