Ontology highlight
ABSTRACT:
SUBMITTER: Larhammar M
PROVIDER: S-EPMC5404924 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Larhammar Martin M Huntwork-Rodriguez Sarah S Jiang Zhiyu Z Solanoy Hilda H Sengupta Ghosh Arundhati A Wang Bei B Kaminker Joshua S JS Huang Kevin K Eastham-Anderson Jeffrey J Siu Michael M Modrusan Zora Z Farley Madeline M MM Tessier-Lavigne Marc M Lewcock Joseph W JW Watkins Trent A TA
eLife 20170425
The PKR-like endoplasmic reticulum kinase (PERK) arm of the Integrated Stress Response (ISR) is implicated in neurodegenerative disease, although the regulators and consequences of PERK activation following neuronal injury are poorly understood. Here we show that PERK signaling is a component of the mouse MAP kinase neuronal stress response controlled by the Dual Leucine Zipper Kinase (DLK) and contributes to DLK-mediated neurodegeneration. We find that DLK-activating insults ranging from nerve ...[more]