Ontology highlight
ABSTRACT:
SUBMITTER: Huang Y
PROVIDER: S-EPMC5404928 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Huang Yun Y Kim Jong Kyoung JK Do Dang Vinh DV Lee Caroline C Penfold Christopher A CA Zylicz Jan J JJ Marioni John C JC Hackett Jamie A JA Surani M Azim MA
eLife 20170321
The maternal-to-zygotic transition (MZT) marks the period when the embryonic genome is activated and acquires control of development. Maternally inherited factors play a key role in this critical developmental process, which occurs at the 2-cell stage in mice. We investigated the function of the maternally inherited factor Stella (encoded by <i>Dppa3</i>) using single-cell/embryo approaches. We show that loss of maternal Stella results in widespread transcriptional mis-regulation and a partial f ...[more]