Ontology highlight
ABSTRACT:
SUBMITTER: Logan T
PROVIDER: S-EPMC5404982 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Logan Todd T Bendor Jacob J Toupin Chantal C Thorn Kurt K Thorn Kurt K Edwards Robert H RH
Nature neuroscience 20170313 5
The protein α-synuclein has a central role in the pathogenesis of Parkinson's disease. Like that of other proteins that accumulate in neurodegenerative disease, however, the function of α-synuclein remains unknown. Localization to the nerve terminal suggests a role in neurotransmitter release, and overexpression inhibits regulated exocytosis, but previous work has failed to identify a clear physiological defect in mice lacking all three synuclein isoforms. Using adrenal chromaffin cells and neur ...[more]