Ontology highlight
ABSTRACT:
SUBMITTER: Wang T
PROVIDER: S-EPMC5405012 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Wang Tianjiao T Lu Ye Y Polk Avery A Chowdhury Pinki P Murga-Zamalloa Carlos C Fujiwara Hiroshi H Suemori Koichiro K Beyersdorf Niklas N Hristov Alexandra C AC Lim Megan S MS Bailey Nathanael G NG Wilcox Ryan A RA
Clinical cancer research : an official journal of the American Association for Cancer Research 20161025 10
<b>Purpose:</b> T-cell lymphomas are a molecularly heterogeneous group of non-Hodgkin lymphomas (NHL) that account for a disproportionate number of NHL disease-related deaths due to their inherent and acquired resistance to standard multiagent chemotherapy regimens. Despite their molecular heterogeneity and frequent loss of various T cell-specific receptors, the T-cell antigen receptor is retained in the majority of these lymphomas. As T-cell receptor (TCR) engagement activates a number of signa ...[more]