Ontology highlight
ABSTRACT:
SUBMITTER: Ohta Y
PROVIDER: S-EPMC5405175 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Ohta Yasuharu Y Taguchi Akihiko A Matsumura Takuro T Nakabayashi Hiroko H Akiyama Masaru M Yamamoto Kaoru K Fujimoto Ruriko R Suetomi Risa R Yanai Akie A Shinoda Koh K Tanizawa Yukio Y
EBioMedicine 20170330
In Wfs1<sup>-/-</sup>A<sup>y</sup>/a islets, in association with endoplasmic reticulum (ER) stress, D-site-binding protein (Dbp) expression decreased and Nuclear Factor IL-3 (Nfil3)/E4 Promoter-binding protein 4 (E4bp4) expression increased, leading to reduced DBP transcriptional activity. Similar alterations were observed with chemically-induced ER stress. Transgenic mice expressing E4BP4 under the control of the mouse insulin I gene promoter (MIP), in which E4BP4 in β-cells is expected to comp ...[more]