Ontology highlight
ABSTRACT:
SUBMITTER: Westwood S
PROVIDER: S-EPMC5405532 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Westwood Sarah S Liu Benjamine B Baird Alison L AL Anand Sneha S Nevado-Holgado Alejo J AJ Newby Danielle D Pikkarainen Maria M Hallikainen Merja M Kuusisto Johanna J Streffer Johannes R JR Novak Gerald G Blennow Kaj K Andreasson Ulf U Zetterberg Henrik H Smith Ulf U Laakso Markku M Soininen Hilkka H Lovestone Simon S
Alzheimer's research & therapy 20170426 1
<h4>Background</h4>Insulin resistance (IR) has previously been associated with an increased risk of developing Alzheimer's disease (AD), although the relationship between IR and AD is not yet clear. Here, we examined the influence of IR on AD using plasma and cerebrospinal fluid (CSF) biomarkers related to IR and AD in cognitively healthy men. We also aimed to characterise the shared protein signatures between IR and AD.<h4>Methods</h4>Fifty-eight cognitively healthy men, 28 IR and 30 non-IR (ag ...[more]