Ontology highlight
ABSTRACT:
SUBMITTER: Guo H
PROVIDER: S-EPMC5405574 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
BioMed research international 20170411
The discovery of cis-regulatory modules (CRMs) is the key to understanding mechanisms of transcription regulation. Since CRMs have specific regulatory structures that are the basis for the regulation of gene expression, how to model the regulatory structure of CRMs has a considerable impact on the performance of CRM identification. The paper proposes a CRM discovery algorithm called ComSPS. ComSPS builds a regulatory structure model of CRMs based on HMM by exploring the rules of CRM transcriptio ...[more]