Ontology highlight
ABSTRACT:
SUBMITTER: Boire A
PROVIDER: S-EPMC5405733 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Boire Adrienne A Zou Yilong Y Shieh Jason J Macalinao Danilo G DG Pentsova Elena E Massagué Joan J
Cell 20170301 6
We molecularly dissected leptomeningeal metastasis, or spread of cancer to the cerebrospinal fluid (CSF), which is a frequent and fatal condition mediated by unknown mechanisms. We selected lung and breast cancer cell lines for the ability to infiltrate and grow in CSF, a remarkably acellular, mitogen-poor metastasis microenvironment. Complement component 3 (C3) was upregulated in four leptomeningeal metastatic models and proved necessary for cancer growth within the leptomeningeal space. In hum ...[more]