Dataset Information

Common eye diseases in older adults of southern Germany: results from the KORA-Age study.

ABSTRACT: Purpose:a population-based study in the region of Augsburg (Germany, KORA) was used to identify the prevalence of eye diseases and their risk factors in a sample of aged individuals. Methods:data originated from the KORA-Age study collected in 2012 and 822 participants (49.6% women, 50.4% men, aged 68-96 years) were asked standardised questions about eye diseases. Positive answers were validated and specified by treating ophthalmologists. Additional information came from laboratory data. Polymorphic markers were tested for candidate genes. Results:we received validations and specifications for 339 participants. The most frequent eye diseases were cataracts (299 cases, 36%), dry eyes (120 cases, 15%), glaucoma (72 cases, 9%) and age-related macular degeneration (AMD) (68 cases, 8%). Almost all participants suffering from glaucoma or from AMD also had cataracts. Cataract surgery was associated with diabetes (in men; OR = 2.24; 95% confidence interval [CI] 1.11-4.53; P = 0.025) and smoking (in women; OR = 6.77; CI 1.62-28.35; P = 0.009). In men, treatments in airway diseases was associated with cataracts (glucocorticoids: OR = 5.29, CI 1.20-23.37; P = 0.028; sympathomimetics: OR = 4.57, CI 1.39-15.00; P = 0.012). Polymorphisms in two genes were associated with AMD (ARMS2: OR = 2.28, CI 1.48-3.51; P = 0.005; CFH: OR = 2.03, CI 1.35-3.06; P = 0.010). Conclusion:combinations of eye diseases were frequent at old age. The importance of classical risk factors like diabetes, hypertension and airway diseases decreased either due to a survivor bias leaving healthier survivors in the older age group, or due to an increased influence of other up to now unknown risk factors.

SUBMITTER: Reitmeir P

PROVIDER: S-EPMC5405752 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Common eye diseases in older adults of southern Germany: results from the KORA-Age study.

Reitmeir Peter P Linkohr Birgit B Heier Margit M Molnos Sophie S Strobl Ralf R Schulz Holger H Breier Michaela M Faus Theresa T Küster Dorothea M DM Wulff Andrea A Grallert Harald H Grill Eva E Peters Annette A Graw Jochen J

Age and ageing 20170501 3

<h4>Purpose</h4>a population-based study in the region of Augsburg (Germany, KORA) was used to identify the prevalence of eye diseases and their risk factors in a sample of aged individuals.<h4>Methods</h4>data originated from the KORA-Age study collected in 2012 and 822 participants (49.6% women, 50.4% men, aged 68-96 years) were asked standardised questions about eye diseases. Positive answers were validated and specified by treating ophthalmologists. Additional information came from laborator ...[more]

PMID: 27974306

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Dataset Information

Common eye diseases in older adults of southern Germany: results from the KORA-Age study.

Publications

Common eye diseases in older adults of southern Germany: results from the KORA-Age study.

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