Transplantation of induced mesenchymal stem cells for treating chronic renal insufficiency.
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ABSTRACT:
SUBMITTER: Pan XH
PROVIDER: S-EPMC5405955 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Transplantation of induced mesenchymal stem cells for treating chronic renal insufficiency.
Pan Xing-Hua XH Zhou Jing J Yao Xiang X Shu Jun J Liu Ju-Fen JF Yang Jian-Yong JY Pang Rong-Qing RQ Ruan Guang-Ping GP
PloS one 20170426 4
Discovering a new cell transplantation approach for treating chronic renal insufficiency is a goal of many nephrologists. In vitro-cultured peripheral blood mononuclear cells (PBMCs) were reprogrammed into induced mesenchymal stem cells (iMSCs) by using natural inducing agents made in our laboratory. The stem cell phenotype of the iMSCs was then identified. Unilateral ureteral obstruction (UUO) was used to create an animal model of chronic renal insufficiency characterized by renal interstitial ...[more]
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