Ontology highlight
ABSTRACT:
SUBMITTER: Garcia-Exposito L
PROVIDER: S-EPMC5406014 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Cell reports 20161101 7
Cancer cells rely on the activation of telomerase or the alternative lengthening of telomeres (ALT) pathways for telomere maintenance and survival. ALT involves homologous recombination (HR)-dependent exchange and/or HR-associated synthesis of telomeric DNA. Utilizing proximity-dependent biotinylation (BioID), we sought to determine the proteome of telomeres in cancer cells that employ these distinct telomere elongation mechanisms. Our analysis reveals that multiple DNA repair networks converge ...[more]