Ontology highlight
ABSTRACT:
SUBMITTER: Scott TA
PROVIDER: S-EPMC5406385 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Scott Timothy A TA Quintaneiro Leonor M LM Norvaisas Povilas P Lui Prudence P PP Wilson Matthew P MP Leung Kit-Yi KY Herrera-Dominguez Lucia L Sudiwala Sonia S Pessia Alberto A Clayton Peter T PT Bryson Kevin K Velagapudi Vidya V Mills Philippa B PB Typas Athanasios A Greene Nicholas D E NDE Cabreiro Filipe F
Cell 20170401 3
Fluoropyrimidines are the first-line treatment for colorectal cancer, but their efficacy is highly variable between patients. We queried whether gut microbes, a known source of inter-individual variability, impacted drug efficacy. Combining two tractable genetic models, the bacterium E. coli and the nematode C. elegans, we performed three-way high-throughput screens that unraveled the complexity underlying host-microbe-drug interactions. We report that microbes can bolster or suppress the effect ...[more]