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Immunological evaluation of peptide vaccination for cancer patients with the HLA -A11⁺ or -A33⁺ allele.

ABSTRACT: The HLA-A11 or -A33 allele is found in approximately 18% or 10% of the Asian population, respectively, but each of which is a minor allele worldwide, and therefore no clinical trials were previously conducted. To develop a therapeutic peptide vaccine for each of them, we investigated immunological responses of advanced cancer patients with the HLA-A11⁺ /A11⁺ (n = 18) or -A33⁺ /A33⁺ (n = 13) allele to personalized peptide vaccine (PPV) regimens. The primary sites of HLA-A11+/A11+ or -A33+/A33+ patients were the colon (n = 4 or 2), stomach (2 or 3), breast (3 or 2), lung and pancreas (2 or 2), and so on. For PPV, a maximum of four peptides were selected from nine different peptides capable of binding to HLA-A11 and -A33 molecules based on the pre-existing peptide-specific IgG responses. There were no severe adverse events related to PPV. At the end of the first cycle, peptide-specific CTL responses were augmented in 4/12 or 2/9 of HLA-A11⁺ /A11⁺ or -A33⁺ /A33⁺ patients, while peptide-specific IgG responses were augmented in 6/14 or 4/10 patients, respectively. Clinical responses consisted of four stable diseases and 14 progressive diseases in HLA-A11⁺ /A11⁺ patients, versus seven and six in -A33⁺ /A33⁺ patients, respectively. Further clinical study of PPV could be recommended because of the safety and positive immunological responses.

SUBMITTER: Sakamoto S

PROVIDER: S-EPMC5406587 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Immunological evaluation of peptide vaccination for cancer patients with the HLA -A11+ or -A33+ allele.

Sakamoto Shinjiro S Matsueda Satoko S Takamori Shinzo S Toh Uhi U Noguchi Masanori M Yutani Shigeru S Yamada Akira A Shichijo Shigeki S Yamada Teppei T Suekane Shigetaka S Kawano Kouichiro K Naitou Masayasu M Sasada Tetsuro T Hattori Noboru N Kohno Nobuoki N Itoh Kyogo K

Cancer science 20170421 4

The HLA-A11 or -A33 allele is found in approximately 18% or 10% of the Asian population, respectively, but each of which is a minor allele worldwide, and therefore no clinical trials were previously conducted. To develop a therapeutic peptide vaccine for each of them, we investigated immunological responses of advanced cancer patients with the HLA-A11+ /A11+ (n = 18) or -A33+ /A33+ (n = 13) allele to personalized peptide vaccine (PPV) regimens. The pri ...[more]

PMID: 28178396

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Dataset Information

Immunological evaluation of peptide vaccination for cancer patients with the HLA -A11⁺ or -A33⁺ allele.

Publications

Immunological evaluation of peptide vaccination for cancer patients with the HLA -A11<sup>+</sup> or -A33<sup>+</sup> allele.

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