Ontology highlight
ABSTRACT:
SUBMITTER: Shikata Y
PROVIDER: S-EPMC5406609 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Cancer science 20170420 4
Xanthohumol (XN), a simple prenylated chalcone, can be isolated from hops and has the potential to be a cancer chemopreventive agent against several human tumor cell lines. We previously identified valosin-containing protein (VCP) as a target of XN; VCP can also play crucial roles in cancer progression and prognosis. Therefore, we investigated the molecular mechanisms governing the contribution of VCP to the antitumor activity of XN. Several human tumor cell lines were treated with XN to investi ...[more]