Dataset Information

Psychological Factors May Play an Important Role in Pediatric Crohn's Disease Symptoms and Disability.

ABSTRACT: OBJECTIVE:To examine the relative contributions of disease activity and psychological factors to self-reported symptoms and disability in children with Crohn's disease. STUDY DESIGN:Participants (n?=?127 children age 8-18 years) completed questionnaires on symptom severity and disability, as well as psychological measures assessing anxiety, depression, pain beliefs and coping. Disease activity was measured by the Pediatric Crohn's Disease Activity Index. Structural equation modeling was used to test the effects of disease activity and psychological factors on symptoms and disability. RESULTS:In the hypothesized model predicting symptoms, psychological factors (??=?0.58; P?

SUBMITTER: van Tilburg MAL

PROVIDER: S-EPMC5407185 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Psychological Factors May Play an Important Role in Pediatric Crohn's Disease Symptoms and Disability.

van Tilburg Miranda A L MAL Claar Robyn Lewis RL Romano Joan M JM Langer Shelby L SL Drossman Douglas A DA Whitehead William E WE Abdullah Bisher B Levy Rona L RL

The Journal of pediatrics 20170224

<h4>Objective</h4>To examine the relative contributions of disease activity and psychological factors to self-reported symptoms and disability in children with Crohn's disease.<h4>Study design</h4>Participants (n = 127 children age 8-18 years) completed questionnaires on symptom severity and disability, as well as psychological measures assessing anxiety, depression, pain beliefs and coping. Disease activity was measured by the Pediatric Crohn's Disease Activity Index. Structural equation modeli ...[more]

PMID: 28238483

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Project description:The viruses that infect bacteria, known as phages, play a critical role in controlling bacterial populations in many diverse environments, including the human body. This control stems not only from phages killing bacteria but also from the formation of lysogens. In this state, the phage replication cycle is suppressed, and the phage genome is maintained in the bacterial cell in a form known as a prophage. Prophages often carry genes that benefit the host bacterial cell, since increasing the survival of the host cell by extension also increases the fitness of the prophage. These highly diverse and beneficial phage genes, which are not required for the life cycle of the phage itself, have been referred to as "morons," as their presence adds "more on" the phage genome in which they are found. While individual phage morons have been shown to contribute to bacterial virulence by a number of different mechanisms, there have been no systematic investigations of their activities. Using a library of phages that infect two different clinical isolates of P. aeruginosa, PAO1 and PA14, we compared the phenotypes imparted by the expression of individual phage morons. We identified morons that inhibit twitching and swimming motilities and observed an inhibition of the production of virulence factors such as rhamnolipids and elastase. This study demonstrates the scope of phage-mediated phenotypic changes and provides a framework for future studies of phage morons.IMPORTANCE Environmental and clinical isolates of the bacterium Pseudomonas aeruginosa frequently contain viruses known as prophages. These prophages can alter the virulence of their bacterial hosts through the expression of nonessential genes known as "morons." In this study, we identified morons in a group of Pseudomonas aeruginosa phages and characterized the effects of their expression on bacterial behaviors. We found that many morons confer selective advantages for the bacterial host, some of which correlate with increased bacterial virulence. This work highlights the symbiotic relationship between bacteria and prophages and illustrates how phage morons can help bacteria adapt to different selective pressures and contribute to human diseases.

Dataset Information

Psychological Factors May Play an Important Role in Pediatric Crohn's Disease Symptoms and Disability.

Publications

Psychological Factors May Play an Important Role in Pediatric Crohn's Disease Symptoms and Disability.

Similar Datasets

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