Dramatic Effect of Oral CSF-1R Kinase Inhibitor on Retinal Microglia Revealed by In Vivo Scanning Laser Ophthalmoscopy.
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ABSTRACT:
SUBMITTER: Ebneter A
PROVIDER: S-EPMC5407246 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
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Dramatic Effect of Oral CSF-1R Kinase Inhibitor on Retinal Microglia Revealed by In Vivo Scanning Laser Ophthalmoscopy.
Ebneter Andreas A Kokona Despina D Jovanovic Joël J Zinkernagel Martin S MS
Translational vision science & technology 20170419 2
This report provides sound evidence that the small molecule pharmaceutical PLX5622, a highly selective CSF-1R kinase inhibitor, crosses the blood-retina barrier and suppresses microglia activity. Members of this class of drug are in advanced clinical development stages and may represent a novel approach to modulate ocular inflammatory processes. ...[more]
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