Ontology highlight
ABSTRACT:
SUBMITTER: Davidson SM
PROVIDER: S-EPMC5407288 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Davidson Shawn M SM Jonas Oliver O Keibler Mark A MA Hou Han Wei HW Luengo Alba A Mayers Jared R JR Wyckoff Jeffrey J Del Rosario Amanda M AM Whitman Matthew M Chin Christopher R CR Condon Kendall J KJ Lammers Alex A Kellersberger Katherine A KA Stall Brian K BK Stephanopoulos Gregory G Bar-Sagi Dafna D Han Jongyoon J Rabinowitz Joshua D JD Cima Michael J MJ Langer Robert R Vander Heiden Matthew G MG
Nature medicine 20161226 2
Mammalian tissues rely on a variety of nutrients to support their physiological functions. It is known that altered metabolism is involved in the pathogenesis of cancer, but which nutrients support the inappropriate growth of intact malignant tumors is incompletely understood. Amino acids are essential nutrients for many cancer cells that can be obtained through the scavenging and catabolism of extracellular protein via macropinocytosis. In particular, macropinocytosis can be a nutrient source f ...[more]