Dataset Information

Oxidized LDL, Gamma-Glutamyltransferase and Adverse Outcomes in Older Adults.

ABSTRACT: OBJECTIVES:Gamma-glutamyltransferase (GGT) is a biomarker of liver disease and oxidative stress which was associated with all-cause and cardiovascular (CV) mortality in the general population and in patients with high risk conditions. This study aims at assessing whether oxLDL modifies the relationship between GGT, all-cause, and CV mortality in elderly individuals from the general population. DESIGN:Observational longitudinal study. SETTING:Population-based cohort of older individuals (>65 years) free of liver disease. PARTICIPANTS:One thousand and thirty-eight individuals from the Invecchiare in Chianti (InCHIANTI) study. MEASUREMENTS:Serum GGT level, oxidized low-density lipoprotein (oxLDL), CV comorbidities, all-cause and CV mortality. RESULTS:The median age of the study population (n = 1,038) was 74 years (inter-quartile range: 69-79), 152 individuals (15%) had past CV events. During a median follow-up of 9 years, 401 individuals died, 168 of them (42%) for CV causes. In adjusted analyses, GGT predicted all-cause mortality (HR for 20 U/L increase in serum GGT: 1.11, 95% CI: 1.02-1.21, P = .02) and CV mortality (HR: 1.17, 95% CI: 1.03-1.33; P = .02). Furthermore, in an analysis for interaction circulating oxLDL amplified the effect of GGT on all-cause mortality (P = .003). CONCLUSION:Circulating oxLDL amplifies the effect of GGT on mortality in the elderly. The mechanism for this association remains unknown and requires further research, including studying the potential role of GGT in oxidative stress. These results are consistent with the hypothesis of a causal role of GGT in the CV morbidity and mortality in older individuals and indicate that oxLDL plays a crucial role in the interpretation of the link between GGT and the risk of adverse clinical events in this population.

SUBMITTER: Spoto B

PROVIDER: S-EPMC5407291 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Oxidized LDL, Gamma-Glutamyltransferase and Adverse Outcomes in Older Adults.

Spoto Belinda B Mattace-Raso Francesco F Sijbrands Eric J EJ D'Arrigo Graziella G Tripepi Giovanni G Volpato Stefano S Bandinelli Stefania S Ferrucci Luigi L Zoccali Carmine C

Journal of the American Geriatrics Society 20170401 4

<h4>Objectives</h4>Gamma-glutamyltransferase (GGT) is a biomarker of liver disease and oxidative stress which was associated with all-cause and cardiovascular (CV) mortality in the general population and in patients with high risk conditions. This study aims at assessing whether oxLDL modifies the relationship between GGT, all-cause, and CV mortality in elderly individuals from the general population.<h4>Design</h4>Observational longitudinal study.<h4>Setting</h4>Population-based cohort of older ...[more]

PMID: 28422277

Similar Datasets

Project description:BackgroundThere is no general agreement on a standard form of functional classification in older adults and is mainly assessed by Activities of Daily Living (ADL) and/or Instrument Activity of Daily Living. A refined classification based on evaluation the limitations of intrinsic capacity, environment and social interaction, could provide a basis to predict the future disability and identify individuals with increased risk of adverse outcomes.MethodsA new functional classification among older adults aged 60 and over was conducted by latent class analysis and compared with the traditional classifications, based on the China Health and Retirement Longitudinal Study. To further investigate the scientific validity of this new classification, associations with 7-year mortality and ADLs impairments among categories were tested by using Survival curves and Cox proportional hazard models. This was followed by the confirmatory analysis related to the prospective data. Competing risk analysis was also performed to analysis the sensitivity to further support our conclusions.ResultsFive categories were identified among 5,992 older adults which gave the best fitting, yielding a significant Bootstrap Likelihood Ratio Test (p < 0.001) and Lo-Mendell-Rubin adjusted likelihood ratio test (p < 0.001), with an entropy over 0.80. The presence of five categories: "health" (34.0%), "sub-disorder status" (36.6%), "acute diseases" (10.3%), "somatic functional disorder" (7.7%), and "viability disorder" (11.4%), which matched well with the functional independence rates by the international classifications. Among them, those in "sub-disorder status" were considered as an intermediate status between disability and health. The findings also revealed that those who were in "acute disease", "somatic functional disorders", "health" and "sub-disorder status" had a significant lower risk of mortality and ADLs limitations than "viability disorder". And the risks gradually increased towards the less functionally independent end of the classification. However, the distribution of characteristics among five categories were in a synchronous change, indicating a stable classification.ConclusionsA new classification representing the functional heterogeneity of older adults could effectively stratify the risk of mortality and ADLs limitations. Identifying the clusters of functional decline might be useful in predicting subsequent ageing trends, designing personalized intervention, and delaying the progression of disability and preventing its occurrence.

Dataset Information

Oxidized LDL, Gamma-Glutamyltransferase and Adverse Outcomes in Older Adults.

Publications

Oxidized LDL, Gamma-Glutamyltransferase and Adverse Outcomes in Older Adults.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets