Targeting the programmed cell death 1 pathway in Hodgkin lymphoma: the place of nivolumab.
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ABSTRACT:
SUBMITTER: Gay ND
PROVIDER: S-EPMC5407507 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
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Targeting the programmed cell death 1 pathway in Hodgkin lymphoma: the place of nivolumab.
Gay Nathan D ND Okada Craig Y CY Chen Andy I AI Scott Emma C EC
Therapeutic advances in hematology 20170328 5
Nivolumab is a humanized immunoglobulin gamma-4 kappa anti-programmed cell death 1 monoclonal antibody that is currently approved in the treatment of several solid tumors and recently gained accelerated approval in classical Hodgkin lymphoma (cHL) that has relapsed or progressed following autologous hematopoietic stem-cell transplantation and post-transplantation brentuximab vedotin. The purpose of this article is to review the immunophysiologic basis, clinical efficacy, and toxicity of nivoluma ...[more]
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