Ontology highlight
ABSTRACT:
SUBMITTER: Cardenal-Munoz E
PROVIDER: S-EPMC5407849 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Cardenal-Muñoz Elena E Arafah Sonia S López-Jiménez Ana Teresa AT Kicka Sébastien S Falaise Alexandra A Bach Frauke F Schaad Olivier O King Jason S JS Hagedorn Monica M Soldati Thierry T
PLoS pathogens 20170417 4
Autophagy is a eukaryotic catabolic process also participating in cell-autonomous defence. Infected host cells generate double-membrane autophagosomes that mature in autolysosomes to engulf, kill and digest cytoplasmic pathogens. However, several bacteria subvert autophagy and benefit from its machinery and functions. Monitoring infection stages by genetics, pharmacology and microscopy, we demonstrate that the ESX-1 secretion system of Mycobacterium marinum, a close relative to M. tuberculosis, ...[more]