Human cardiac fibroblasts adaptive responses to controlled combined mechanical strain and oxygen changes in vitro.
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ABSTRACT:
SUBMITTER: Ugolini GS
PROVIDER: S-EPMC5407858 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
Human cardiac fibroblasts adaptive responses to controlled combined mechanical strain and oxygen changes in vitro.
Ugolini Giovanni Stefano GS Pavesi Andrea A Rasponi Marco M Fiore Gianfranco Beniamino GB Kamm Roger R Soncini Monica M
eLife 20170318
Upon cardiac pathological conditions such as ischemia, microenvironmental changes instruct a series of cellular responses that trigger cardiac fibroblasts-mediated tissue adaptation and inflammation. A comprehensive model of how early environmental changes may induce cardiac fibroblasts (CF) pathological responses is far from being elucidated, partly due to the lack of approaches involving complex and simultaneous environmental stimulation. Here, we provide a first analysis of human primary CF b ...[more]
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