Ontology highlight
ABSTRACT:
SUBMITTER: Velez-Ortega AC
PROVIDER: S-EPMC5407859 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Vélez-Ortega A Catalina AC Freeman Mary J MJ Indzhykulian Artur A AA Grossheim Jonathan M JM Frolenkov Gregory I GI
eLife 20170328
Mechanotransducer channels at the tips of sensory stereocilia of inner ear hair cells are gated by the tension of 'tip links' interconnecting stereocilia. To ensure maximal sensitivity, tip links are tensioned at rest, resulting in a continuous influx of Ca<sup>2+</sup> into the cell. Here, we show that this constitutive Ca<sup>2+</sup> influx, usually considered as potentially deleterious for hair cells, is in fact essential for stereocilia stability. In the auditory hair cells of young postnat ...[more]