Ontology highlight
ABSTRACT:
SUBMITTER: Freire-Pritchett P
PROVIDER: S-EPMC5407860 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Freire-Pritchett Paula P Schoenfelder Stefan S Várnai Csilla C Wingett Steven W SW Cairns Jonathan J Collier Amanda J AJ García-Vílchez Raquel R Furlan-Magaril Mayra M Osborne Cameron S CS Fraser Peter P Rugg-Gunn Peter J PJ Spivakov Mikhail M
eLife 20170323
Long-range <i>cis-</i>regulatory elements such as enhancers coordinate cell-specific transcriptional programmes by engaging in DNA looping interactions with target promoters. Deciphering the interplay between the promoter connectivity and activity of <i>cis-</i>regulatory elements during lineage commitment is crucial for understanding developmental transcriptional control. Here, we use Promoter Capture Hi-C to generate a high-resolution atlas of chromosomal interactions involving ~22,000 gene pr ...[more]