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Managing Renal Cell Carcinoma Associated Paraneoplastic Syndrome with Nephron-sparing Surgery in a Patient with von Hippel-Lindau.


ABSTRACT: A patient with germline von Hippel-Lindau (VHL) gene alteration and history of multiple tumors present with classical paraneoplastic syndrome (PNS) associated with renal cell carcinoma (RCC). She underwent open nephron sparing surgery with resolution of symptoms. She remained without recurrence of RCC for the initial 2 years of her follow-up. To the best of our knowledge, this case represents the first in which PNS was specifically resolved using a partial nephrectomy in a patient with VHL. This case report provides initial evidence for the potential role of nephron sparing surgery in the management of paraneoplastic symptoms associated with hereditary RCC.

SUBMITTER: DiBianco JM 

PROVIDER: S-EPMC5408158 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Managing Renal Cell Carcinoma Associated Paraneoplastic Syndrome with Nephron-sparing Surgery in a Patient with von Hippel-Lindau.

DiBianco John M JM   An Julie Y JY   Tanakchi Sally S   Stanik Zachary Z   McGowan Aidan A   Maruf Mahir M   Sidana Abhinav A   Jain Amit Lodha AL   Muthigi Akhil A   George Arvin K AK   Bayne Christopher C   Linehan W Marston WM   Boyle Shawna L SL   Metwalli Adam R AR  

Urology case reports 20170427


A patient with germline von Hippel-Lindau (VHL) gene alteration and history of multiple tumors present with classical paraneoplastic syndrome (PNS) associated with renal cell carcinoma (RCC). She underwent open nephron sparing surgery with resolution of symptoms. She remained without recurrence of RCC for the initial 2 years of her follow-up. To the best of our knowledge, this case represents the first in which PNS was specifically resolved using a partial nephrectomy in a patient with VHL. This  ...[more]

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