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Four Aromatic Sulfates with an Inhibitory Effect against HCV NS3 Helicase from the Crinoid Alloeocomatella polycladia.

ABSTRACT: Bioassay-guided separation of a lipophilic extract of the crinoid Alloeocomatella polycladia, inhibiting the activity of HCV NS3 helicase, yielded two groups of molecules: cholesterol sulfate and four new aromatic sulfates 1-4. The structures of the aromatics were elucidated by spectroscopic analysis in addition to theoretical studies. The aromatic sulfates 1-4 showed moderate inhibition against NS3 helicase with IC₅₀ values of 71, 95, 7, and 5 ?M, respectively.

SUBMITTER: Hermawan I

PROVIDER: S-EPMC5408263 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Four Aromatic Sulfates with an Inhibitory Effect against HCV NS3 Helicase from the Crinoid Alloeocomatella polycladia.

Hermawan Idam I Furuta Atsushi A Higashi Masahiro M Fujita Yoshihisa Y Akimitsu Nobuyoshi N Yamashita Atsuya A Moriishi Kohji K Tsuneda Satoshi S Tani Hidenori H Nakakoshi Masamichi M Tsubuki Masayoshi M Sekiguchi Yuji Y Noda Naohiro N Tanaka Junichi J

Marine drugs 20170411 4

Bioassay-guided separation of a lipophilic extract of the crinoid Alloeocomatella polycladia, inhibiting the activity of HCV NS3 helicase, yielded two groups of molecules: cholesterol sulfate and four new aromatic sulfates 1-4. The structures of the aromatics were elucidated by spectroscopic analysis in addition to theoretical studies. The aromatic sulfates 1-4 showed moderate inhibition against NS3 helicase with IC50 values of 71, 95, 7, and 5 μM, r ...[more]

PMID: 28398249

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