Dataset Information

PEAR1 is not a major susceptibility gene for cardiovascular disease in a Flemish population.

ABSTRACT:

Background

Platelet Endothelial Aggregation Receptor 1 (PEAR1), a membrane protein highly expressed in platelets and endothelial cells, plays a role in platelet contact-induced activation, sustained platelet aggregation and endothelial function. Previous reports implicate PEAR1 rs12041331 as a variant influencing risk in patients with coronary heart disease. We investigated whether genetic variation in PEAR1 predicts cardiovascular outcome in a white population.

Methods

In 1938 participants enrolled in the Flemish Study on Environment, Genes and Health Outcomes (51.3% women; mean age 43.6 years), we genotyped 9 tagging SNPs in PEAR1, measured baseline cardiovascular risk factors, and recorded Cardiovascular disease incidence. For SNPs, we contrasted cardiovascular disease incidence of minor-allele heterozygotes and homozygotes (variant) vs. major-allele homozygotes (reference) and for haplotypes carriers vs. non-carriers. In adjusted analyses, we accounted for family clusters and baseline covariables, including sex, age, body mass index, mean arterial pressure, the total-to-HDL cholesterol ratio, smoking and drinking, antihypertensive drug treatment, and history of cardiovascular disease and diabetes mellitus.

Results

Over a median follow-up of 15.3 years, 238 died and 181 experienced a major cardiovascular endpoint. The multivariable-adjusted hazard ratios of eight PEAR1 SNPs, including rs12566888, ranged from 0.87 to 1.07 (P ≥0.35) and from 0.78 to 1.30 (P ≥0.15), respectively. The hazard ratios of three haplotypes with frequency ≥10% ranged from 0.93 to 1.11 (P ≥0.49) for mortality and from 0.84 to 1.03 (P ≥0.29) for a cardiovascular complications. These results were not influenced by intake of antiplatelet drugs, nonsteroidal anti-inflammatory drugs, or both (P-values for interaction ≥ 0.056).

Conclusions

In a White population, we could not replicate previous reports from experimental studies or obtained in patients suggesting that PEAR1 might be a susceptibility gene for cardiovascular complications.

SUBMITTER: Yang WY

PROVIDER: S-EPMC5408434 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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PEAR1 is not a major susceptibility gene for cardiovascular disease in a Flemish population.

Yang Wen-Yi WY Petit Thibault T Cauwenberghs Nicholas N Zhang Zhen-Yu ZY Sheng Chang-Sheng CS Thijs Lutgarde L Salvi Erika E Izzi Benedetta B Vandenbriele Christophe C Wei Fang-Fei FF Gu Yu-Mei YM Jacobs Lotte L Citterio Lorena L Delli Carpini Simona S Barlassina Cristina C Cusi Daniele D Hoylaerts Marc F MF Verhamme Peter P Kuznetsova Tatiana T Staessen Jan A JA

BMC medical genetics 20170427 1

<h4>Background</h4>Platelet Endothelial Aggregation Receptor 1 (PEAR1), a membrane protein highly expressed in platelets and endothelial cells, plays a role in platelet contact-induced activation, sustained platelet aggregation and endothelial function. Previous reports implicate PEAR1 rs12041331 as a variant influencing risk in patients with coronary heart disease. We investigated whether genetic variation in PEAR1 predicts cardiovascular outcome in a white population.<h4>Methods</h4>In 1938 pa ...[more]

PMID: 28449647

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Dataset Information

PEAR1 is not a major susceptibility gene for cardiovascular disease in a Flemish population.

Background

Methods

Results

Conclusions

Publications

PEAR1 is not a major susceptibility gene for cardiovascular disease in a Flemish population.

Similar Datasets

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