Crystal Structure of Hypusine-Containing Translation Factor eIF5A Bound to a Rotated Eukaryotic Ribosome.
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ABSTRACT:
SUBMITTER: Melnikov S
PROVIDER: S-EPMC5408928 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Publications
Crystal Structure of Hypusine-Containing Translation Factor eIF5A Bound to a Rotated Eukaryotic Ribosome.
Melnikov Sergey S Mailliot Justine J Shin Byung-Sik BS Rigger Lukas L Yusupova Gulnara G Micura Ronald R Dever Thomas E TE Yusupov Marat M
Journal of molecular biology 20160516 18
Eukaryotic translation initiation factor eIF5A promotes protein synthesis by resolving polyproline-induced ribosomal stalling. Here, we report a 3.25-Å resolution crystal structure of eIF5A bound to the yeast 80S ribosome. The structure reveals a previously unseen conformation of an eIF5A-ribosome complex and highlights a possible functional link between conformational changes of the ribosome during protein synthesis and the eIF5A-ribosome association. ...[more]
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