Maternal and Fetal Folate, Vitamin B₁₂, and Homocysteine Concentrations and Childhood Kidney Outcomes.

ABSTRACT:

Background

Folate, vitamin B₁₂, and homocysteine concentrations during pregnancy are important factors for early development and may persistently influence kidney function in the offspring. We examined the associations of folate, vitamin B₁₂, and homocysteine concentrations during pregnancy with kidney outcomes in school-aged children.

Study design

Population-based prospective cohort study from fetal life onward.

Settings & participants

This study was performed among 4,226 pregnant women and their children.

Predictors

Folate, vitamin B₁₂, and homocysteine blood concentrations measured in early pregnancy (median gestational age, 13.2 [IQR, 12.2-14.8] weeks) and at birth (cord blood).

Outcomes & measurements

At the median a

SUBMITTER: Miliku K 

PROVIDER: S-EPMC5408932 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature