Loss of Arf4 causes severe degeneration of the exocrine pancreas but not cystic kidney disease or retinal degeneration.
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ABSTRACT:
SUBMITTER: Pearring JN
PROVIDER: S-EPMC5409180 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
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Loss of Arf4 causes severe degeneration of the exocrine pancreas but not cystic kidney disease or retinal degeneration.
Pearring Jillian N JN San Agustin Jovenal T JT Lobanova Ekaterina S ES Gabriel Christopher J CJ Lieu Eric C EC Monis William J WJ Stuck Michael W MW Strittmatter Lara L Jaber Samer M SM Arshavsky Vadim Y VY Pazour Gregory J GJ
PLoS genetics 20170414 4
Arf4 is proposed to be a critical regulator of membrane protein trafficking in early secretory pathway. More recently, Arf4 was also implicated in regulating ciliary trafficking, however, this has not been comprehensively tested in vivo. To directly address Arf4's role in ciliary transport, we deleted Arf4 specifically in either rod photoreceptor cells, kidney, or globally during the early postnatal period. Arf4 deletion in photoreceptors did not cause protein mislocalization or retinal degenera ...[more]
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