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Diffusion tensor spectroscopic imaging of the human brain in children and adults.


ABSTRACT: PURPOSE:We developed diffusion tensor spectroscopic imaging (DTSI), based on proton-echo-planar-spectroscopic imaging (PEPSI), and evaluated the feasibility of mapping brain metabolite diffusion in adults and children. METHODS:PRESS prelocalized DTSI at 3 Tesla (T) was performed using navigator-based correction of movement-related phase errors and cardiac gating with compensation for repetition time (TR) related variability in T1 saturation. Mean diffusivity (MD) and fractional anisotropy (FA) of total N-acetyl-aspartate (tNAA), total creatine (tCr), and total choline (tCho) were measured in eight adults (17-60 years) and 10 children (3-24 months) using bmax ?=?1734 s/mm2 , 1 cc and 4.5 cc voxel sizes, with nominal scan times of 17?min and 8:24?min. Residual movement-related phase encoding ghosting (PEG) was used as a regressor across scans to correct overestimation of MD. RESULTS:After correction for PEG, metabolite slice-averaged MD estimated at 20% PEG were lower (P?

SUBMITTER: Fotso K 

PROVIDER: S-EPMC5409876 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Diffusion tensor spectroscopic imaging of the human brain in children and adults.

Fotso Kevin K   Dager Stephen R SR   Landow Alec A   Ackley Elena E   Myers Orrin O   Dixon Mindy M   Shaw Dennis D   Corrigan Neva M NM   Posse Stefan S  

Magnetic resonance in medicine 20161028 4


<h4>Purpose</h4>We developed diffusion tensor spectroscopic imaging (DTSI), based on proton-echo-planar-spectroscopic imaging (PEPSI), and evaluated the feasibility of mapping brain metabolite diffusion in adults and children.<h4>Methods</h4>PRESS prelocalized DTSI at 3 Tesla (T) was performed using navigator-based correction of movement-related phase errors and cardiac gating with compensation for repetition time (TR) related variability in T<sub>1</sub> saturation. Mean diffusivity (MD) and fr  ...[more]

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