Ontology highlight
ABSTRACT:
SUBMITTER: Pathak D
PROVIDER: S-EPMC5409983 | biostudies-literature | 2017 Mar-Apr
REPOSITORIES: biostudies-literature
eNeuro 20170301 2
Increased α-synuclein (αsyn) and mitochondrial dysfunction play central roles in the pathogenesis of Parkinson's disease (PD), and lowering αsyn is under intensive investigation as a therapeutic strategy for PD. Increased αsyn levels disrupt mitochondria and impair respiration, while reduced αsyn protects against mitochondrial toxins, suggesting that interactions between αsyn and mitochondria influences the pathologic and physiologic functions of αsyn. However, we do not know if αsyn affects nor ...[more]