HMGCS2 enhances invasion and metastasis via direct interaction with PPAR? to activate Src signaling in colorectal cancer and oral cancer.
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ABSTRACT:
SUBMITTER: Chen SW
PROVIDER: S-EPMC5410236 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
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HMGCS2 enhances invasion and metastasis via direct interaction with PPARα to activate Src signaling in colorectal cancer and oral cancer.
Chen Shih-Wen SW Chou Chiang-Ting CT Chang Cheng-Chi CC Li Yue-Ju YJ Chen Szu-Ta ST Lin I-Ching IC Kok Sang-Heng SH Cheng Shih-Jung SJ Lee Jang-Jaer JJ Wu Tai-Sheng TS Kuo Min-Liang ML Lin Been-Ren BR
Oncotarget 20170401 14
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (HMGCS2) is the rate-limiting enzyme of ketogenesis. Growing evidence indicates that HMGCS2 may be involved in cancer progression, but its exact role is largely unknown. In this study, we demonstrate that HMGCS2 mRNA expression is associated with poor clinical prognosis and outcomes in patients with colorectal cancer (CRC) and oral squamous cell carcinoma (OSCC). In vitro, ectopic expression of HMGCS2 enhanced cancer cell motility in a ketoge ...[more]
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