Acceleration of leukocytes' epigenetic age as an early tumor and sex-specific marker of breast and colorectal cancer.
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ABSTRACT:
SUBMITTER: Durso DF
PROVIDER: S-EPMC5410300 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Publications
Acceleration of leukocytes' epigenetic age as an early tumor and sex-specific marker of breast and colorectal cancer.
Durso Danielle Fernandes DF Bacalini Maria Giulia MG Sala Claudia C Pirazzini Chiara C Marasco Elena E Bonafé Massimiliano M do Valle Ítalo Faria ÍF Gentilini Davide D Castellani Gastone G Faria Ana Maria Caetano AMC Franceschi Claudio C Garagnani Paolo P Nardini Christine C
Oncotarget 20170401 14
Changes in blood epigenetic age have been associated with several pathological conditions and have recently been described to anticipate cancer development. In this work, we analyze a publicly available leukocytes methylation dataset to evaluate the relation between DNA methylation age and the prospective development of specific types of cancer. We calculated DNA methylation age acceleration using five state-of-the-art estimators (three multi-site: Horvath, Hannum, Weidner; and two CpG specific: ...[more]
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