Ontology highlight
ABSTRACT:
SUBMITTER: Zemmour D
PROVIDER: S-EPMC5410798 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20170410 17
A combination of transcription factors, enhancers, and epigenetic marks determines the expression of the key transcription factor FoxP3 in regulatory T cells (Tregs). Adding an additional layer of complexity, the long noncoding RNA (lncRNA) <i>Flicr</i> (<i>Foxp3</i> long intergenic noncoding RNA) is a negative regulator that tunes <i>Foxp3</i> expression, resulting in a subset of Tregs with twofold- to fivefold-lower levels of FoxP3 protein. The impact of <i>Flicr</i> is particularly marked in ...[more]