Skn-1 is required for interneuron sensory integration and foraging behavior in Caenorhabditis elegans.
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ABSTRACT:
SUBMITTER: Wilson MA
PROVIDER: S-EPMC5411085 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
skn-1 is required for interneuron sensory integration and foraging behavior in Caenorhabditis elegans.
Wilson Mark A MA Iser Wendy B WB Son Tae Gen TG Logie Anne A Cabral-Costa Joao V JV Mattson Mark P MP Camandola Simonetta S
PloS one 20170501 5
Nrf2/skn-1, a transcription factor known to mediate adaptive responses of cells to stress, also regulates energy metabolism in response to changes in nutrient availability. The ability to locate food sources depends upon chemosensation. Here we show that Nrf2/skn-1 is expressed in olfactory interneurons, and is required for proper integration of multiple food-related sensory cues in Caenorhabditis elegans. Compared to wild type worms, skn-1 mutants fail to perceive that food density is limiting, ...[more]
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