Identification and validation of clinically meaningful benchmarks in the 12-item Multiple Sclerosis Walking Scale.

ABSTRACT:

Background

The 12-item Multiple Sclerosis Walking Scale (12-MSWS) is a validated questionnaire which assessed walking function; it has been widely adopted in multiple sclerosis (MS) clinical research.

Objective

Identify and validate clinically meaningful 12-MSWS benchmarks in MS.

Methods

Cross-sectional study of 159 MS patients permitted identification of clinically meaningful 12-MSWS benchmarks based on their relationship to real-life anchors. Identified 12-MSWS benchmarks were then validated in a second population of 96 subjects using measures of ambulation, cognition, and patient-reported outcomes.

Results

12-MSWS score of 0-24.99 was associated with working outside the home and assistance-free mobility; 25-49.99 was associated with gait disability and diffi

SUBMITTER: Goldman MD 

PROVIDER: S-EPMC5411321 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature