IL-17 Signaling: The Yin and the Yang.
Ontology highlight
ABSTRACT:
SUBMITTER: Amatya N
PROVIDER: S-EPMC5411326 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Publications
IL-17 Signaling: The Yin and the Yang.
Amatya Nilesh N Garg Abhishek V AV Gaffen Sarah L SL
Trends in immunology 20170220 5
Interleukin (IL)-17 is the founding member of a novel family of inflammatory cytokines. While the proinflammatory properties of IL-17 are key to its host-protective capacity, unrestrained IL-17 signaling is associated with immunopathology, autoimmune disease, and cancer progression. In this review we discuss both the activators and the inhibitors of IL-17 signal transduction, and also the physiological implications of these events. We highlight the surprisingly diverse means by which these regul ...[more]
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