Dataset Information

Increased Gamma Connectivity in the Human Prefrontal Cortex during the Bereitschaftspotential.

ABSTRACT: The Bereitschaftspotential (BP) is a slow negative cortical potential preceding voluntary movement. Since movement preparation is dependent upon the synchronous activity of a variety of neurons, BP may develop through the exchange of information among motor-related neurons. However, the relationship between BP and information flow is not yet well-known. In the present study, we aimed to investigate how the connectivity in the prefrontal cortex (PFC) changes during the occurrence of BP. Electrocorticography (ECoG) was recorded in five patients with epilepsy. The subjects performed self-paced hand grasping. We compared the intraregional connectivity between PFC and non-PFC regions using partial directed coherence. In the PFC, the connectivity of beta and gamma bands in the BP period increased by an average of 24.4% compared with the baseline connectivity. Conversely, gamma connectivity in non-PFC regions decreased by 31.4%. Moreover, the intraregional connectivity in the PFC increased according to the stage of BP. The increased gamma band connectivity in the PFC implies that the increased communication among neurons in the PFC is associated with development of BP. Intraregional connectivity as one of the factors involved in voluntary movement may reflect the activation of brain networks related to movement preparation in PFC.

SUBMITTER: Kim K

PROVIDER: S-EPMC5411441 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Increased Gamma Connectivity in the Human Prefrontal Cortex during the Bereitschaftspotential.

Kim Kisun K Kim June Sic JS Chung Chun Kee CK

Frontiers in human neuroscience 20170502

The Bereitschaftspotential (BP) is a slow negative cortical potential preceding voluntary movement. Since movement preparation is dependent upon the synchronous activity of a variety of neurons, BP may develop through the exchange of information among motor-related neurons. However, the relationship between BP and information flow is not yet well-known. In the present study, we aimed to investigate how the connectivity in the prefrontal cortex (PFC) changes during the occurrence of BP. Electroco ...[more]

PMID: 28512401

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Project description:Working memory is essential for many of our distinctly human abilities, including reasoning, problem solving, and planning. Research spanning many decades has helped to refine our understanding of this high-level function as comprising several hierarchically organized components, some which maintain information in the conscious mind, and others which manipulate and reorganize this information in useful ways. In the neocortex, these processes are likely implemented by a distributed frontoparietal network, with more posterior regions serving to maintain volatile information, and more anterior regions subserving the manipulation of this information. Recent meta-analytic findings have identified the anterior lateral prefrontal cortex, in particular, as being generally engaged by working memory tasks, while the posterior lateral prefrontal cortex was more strongly associated with the cognitive load required by these tasks. These findings suggest specific roles for these regions in the cognitive control processes underlying working memory. To further characterize these regions, we applied three distinct seed-based methods for determining cortical connectivity. Specifically, we employed meta-analytic connectivity mapping across task-based fMRI experiments, resting-state BOLD correlations, and VBM-based structural covariance. We found a frontoparietal pattern of convergence which strongly resembled the working memory networks identified in previous research. A contrast between anterior and posterior parts of the lateral prefrontal cortex revealed distinct connectivity patterns consistent with the idea of a hierarchical organization of frontoparietal networks. Moreover, we found a distributed network that was anticorrelated with the anterior seed region, which included most of the default mode network and a subcomponent related to social and emotional processing. These findings fit well with the internal attention model of working memory, in which representation of information is processed according to an anteroposterior gradient of abstract-to-concrete representations.

Dataset Information

Increased Gamma Connectivity in the Human Prefrontal Cortex during the Bereitschaftspotential.

Publications

Increased Gamma Connectivity in the Human Prefrontal Cortex during the Bereitschaftspotential.

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